New Delhi Metallo-β-Lactamase, Ontario, Canada

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New Delhi Metallo-β-Lactamase, Ontario, Canada

To the Editor: The New Delhi metallo-β-lactamase (NDM-1) was fi rst characterized in 2009 from Kleb-siella pneumoniae and Escherichia coli isolated from a patient in Sweden who had received medical care in New Delhi, India (1). Further studies have shown broad dissemination of this β-lactamase gene (bla NDM-1) in India, Pakistan, Bangladesh, and the United Kingdom (2). Additional isolates have ...

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New Delhi metallo-β-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection.

New Delhi metallo-β-lactamase-1 (NDM-1) is a recently identified metallo-β-lactamase that confers resistance to carbapenems and all other β-lactam antibiotics, with the exception of aztreonam. NDM-1 is also associated with resistance to many other classes of antibiotics. The enzyme was first identified in organisms isolated from a patient in Sweden who had previously received medical treatment ...

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New Delhi metallo-β-lactamase-1: detection and prevention.

1240 CMAJ, August 9, 2011, 183(11) © 2011 Canadian Medical Association or its licensors The advent of New Delhi metallo-β lactamase-1 (NDM-1) as a new mechanism of microbial resistance went mostly unmarked, despite it being plasmidmediated, highly transferable and able to confer resistance to most antibiotics (with the exceptions of colistin and tigecycline). However, after the Indian subcontin...

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Emergence of New Delhi Metallo-β-Lactamase, Austria

To the Editor: Extended-spectrum β-lactamase–producing Enter-obacteriaceae strains have emerged as a major public health problem throughout the world, particularly in India and Pakistan. The widespread use of carbapenems, the only agents reliably active against these bacteria, resulted in the emergence of a new resistance mechanism. New Delhi metallo-β-lactamase (NDM-1) was fi rst detected in a...

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New Delhi Metallo-β-Lactamase–producing Enterobacteriaceae, United States

We characterized 9 New Delhi metallo-β-lactamase-producing Enterobacteriaceae (5 Klebsiella pneumoniae, 2 Escherichia coli, 1 Enterobacter cloacae, 1 Salmonella enterica serovar Senftenberg) isolates identified in the United States and cultured from 8 patients in 5 states during April 2009-March 2011. Isolates were resistant to β-lactams, fluoroquinolones, and aminoglycosides, demonstrated MICs...

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ژورنال

عنوان ژورنال: Emerging Infectious Diseases

سال: 2011

ISSN: 1080-6040,1080-6059

DOI: 10.3201/eid1702.101561